TY - JOUR T1 - Amfifil polimer kotérhálók: egy újszerű nanoszerkezetű anyagcsoport JF - Magyar Kémiai Folyóirat - Kémiai Közlemények Y1 - 2015 A1 - Szabó, Ákos A1 - Mezey, Péter A1 - Fodor, Csaba A1 - Domján, Attila A1 - Kali, Gergely A1 - Stumphauser, Tímea A1 - Erdődi, Gábor A1 - Thomann, Ralf A1 - Németh, Péter A1 - Szanka, István A1 - Illés, Gergely A1 - Haraszti, Márton A1 - Pásztor, Szabolcs A1 - Bóta, Attila A1 - András Wacha A1 - Süvegh, Károly A1 - Iván, Béla KW - no-peer-review VL - 121 ER - TY - JOUR T1 - Inherently fluorescent and porous zirconia colloids: preparation, characterization and drug adsorption studies JF - J. Mater. Chem. B Y1 - 2015 A1 - Naszályi Nagy, Lívia A1 - Mihály, Judith A1 - Polyák, András A1 - Debreczeni, Balázs A1 - Császár, Barbara A1 - Szigyártó, Imola Csilla A1 - András Wacha A1 - Czégény, Zsuzsanna A1 - Jakab, Emma A1 - Klébert, Szilvia A1 - Drotár, Eszter A1 - Dabasi, G A1 - Bóta, Attila A1 - Balogh, Lajos A1 - Kiss, Éva KW - peer-reviewed AB - Porous, fluorescent zirconia particles of nearly 380 nm diameter were prepared without template molecules or labeling dyes. The porous structure is the result of aggregation-induced particle formation. The inherent fluorescence is assigned to coordinatively unsaturated Zr4+ ions at the sol–{}gel derived ZrO2 surface. After physico-chemical characterization of the native zirconia particles carboxyl and/or amine bearing drug molecules (D,L-\ensuremath{\alpha}-difluoromethylornithine –{} DFMO, ursolic acid –{} UA and doxorubicin –{} DOX) were adsorbed onto their surface, and the products were analyzed with Fourier-transform infrared spectroscopy (FTIR), thermogravimetry (TG), small-angle X-ray scattering (SAXS), fluorimetry and zeta potential vs. pH measurements. We have found that DOX complexes coordinatively unsaturated Zr4+ ions without dislocating them, while carboxyl-bearing drugs interact with basic surface Zr–{}OH sites eliminating some of the carbonate species. The adsorption of UA at the zirconia surface shifts considerably the isoelectric point of the surface and thus provides kinetic stability to the particles at physiological pH. An in vivo biodistribution study in two healthy dogs performed by SPECT/CT detection after 99mTc labeling of the nanocarriers has shown the possibility of drug delivery application. VL - 3 ER - TY - JOUR T1 - Vanadium dispersion and catalytic activity of Pd/VOx/SBA-15 catalysts in the Wacker oxidation of ethylene JF - Microporous and Mesoporous Materials Y1 - 2015 A1 - Barthos, Róbert A1 - Hegyessy, András A1 - Klébert, Szilvia A1 - Valyon, József KW - H2-TPR KW - Pd/V catalysts KW - SBA-15 KW - UV–Vis KW - Wacker oxidation AB - Transmission electron microscopy (TEM), X-ray diffractometry (XRD), in situ diffuse reflectance ultra violet – visible (UV–Vis) spectroscopy, and temperature-programmed reduction by hydrogen (H2-TPR) were used to identify the vanadia forms in vanadium-containing SBA-15 preparations (VOx/SBA-15). Wacker type supported Pd/VOx/SBA-15 catalysts were obtained by introducing Pd into VOx/SBA-15 samples using conventional impregnation method. The activity of the catalysts was tested in the gas phase partial oxidation of ethylene by O2 in the presence of H2O (Wacker oxidation). VOx/SBA-15 sample was obtained by micelle-templated synthesis using vanadium-containing synthesis gel. The vanadium became incorporated in the silica structure from the gel in near to atomic dispersion. This catalyst was quite active in ethylene oxidation to CO2 but had low Wacker activity. Isolated, polymeric and bulk vanadia species were identified in the VOx/SBA-15 prepared by wet impregnation/calcination method. The specific surface area of the sample was found to be smaller than that of the neat SBA-15 support because some pores were blocked by vanadia agglomerates. The corresponding Pd/VOx/SBA-15 catalyst showed high selectivity for acetaldehyde formation but the activity was relatively low due to low accessible active surface. A third VOx/SBA-15 sample was obtained by applying directed surface reaction between silanol groups of dehydrated SBA-15 and anhydrous solution of vanadyl acetylacetonate. Large number of accessible Pd/VOx sites were present in the corresponding Pd/VOx/SBA-15 catalyst. Latter catalyst induced ethylene oxidation to acetaldehyde with high yield at temperatures ≤160 °C and with good yield to acetic acid at temperatures ≥160 °C. VL - 207 SN - 1387-1811 UR - http://www.sciencedirect.com/science/article/pii/S1387181115000050 JO - Microporous and Mesoporous Materials ER - TY - JOUR T1 - Effect of metal oxide on surface area and pore size of water-dispersible colloids from three German silt loam topsoils JF - Geoderma Y1 - 2014 A1 - Jiang, Canlan A1 - Séquaris, Jean-Marie A1 - András Wacha A1 - Bóta, Attila A1 - Vereecken, Harry A1 - Klumpp, Erwin KW - CREDO VL - 235-236 UR - http://linkinghub.elsevier.com/retrieve/pii/S0016706114002882 ER - TY - JOUR T1 - Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones JF - Journal of Biological ChemistryJournal of Biological Chemistry Y1 - 2013 A1 - Longstaff, Colin A1 - Varjú, Imre A1 - Sótonyi, Péter A1 - Szabó, László A1 - Krumrey, Michael A1 - Hoell, Armin A1 - Bóta, Attila A1 - Varga, Zoltán A1 - Komorowicz, Erzsébet A1 - Kolev, Krasimir KW - DNA KW - Fibrinolysis KW - Histones KW - Neutrophil KW - Neutrophil Extracellular Trap KW - Tissue Plasminogen Activator (tPA) AB -

Neutrophil extracellular traps are networks of DNA and associated proteins produced by nucleosome release from activated neutrophils in response to infection stimuli and have recently been identified as key mediators between innate immunity, inflammation, and hemostasis. The interaction of DNA and histones with a number of hemostatic factors has been shown to promote clotting and is associated with increased thrombosis, but little is known about the effects of DNA and histones on the regulation of fibrin stability and fibrinolysis. Here we demonstrate that the addition of histone-DNA complexes to fibrin results in thicker fibers (increase in median diameter from 84 to 123 nm according to scanning electron microscopy data) accompanied by improved stability and rigidity (the critical shear stress causing loss of fibrin viscosity increases from 150 to 376 Pa whereas the storage modulus of the gel increases from 62 to 82 pascals according to oscillation rheometric data). The effects of DNA and histones alone are subtle and suggest that histones affect clot structure whereas DNA changes the way clots are lysed. The combination of histones + DNA significantly prolongs clot lysis. Isothermal titration and confocal microscopy studies suggest that histones and DNA bind large fibrin degradation products with 191 and 136 nm dissociation constants, respectively, interactions that inhibit clot lysis. Heparin, which is known to interfere with the formation of neutrophil extracellular traps, appears to prolong lysis time at a concentration favoring ternary histone-DNA-heparin complex formation, and DNase effectively promotes clot lysis in combination with tissue plasminogen activator.

VL - 288 SN - 0021-9258, 1083-351X UR - http://www.jbc.org/content/288/10/6946 IS - 10 JO - J. Biol. Chem. ER - TY - JOUR T1 - A Closer Look at the Structure of Sterically Stabilized Liposomes: A Small-Angle X-ray Scattering Study JF - The Journal of Physical Chemistry BThe Journal of Physical Chemistry B Y1 - 2010 A1 - Varga, Zoltán A1 - Berényi, Szilvia A1 - Szokol, Bálint A1 - Őrfi, László A1 - Kéri, György A1 - Peták, István A1 - Hoell, Armin A1 - Bóta, Attila VL - 114 SN - 1520-6106, 1520-5207 UR - http://pubs.acs.org/doi/abs/10.1021/jp9109207 IS - 20 JO - A Closer Look at the Structure of Sterically Stabilized Liposomes ER - TY - BOOK T1 - X-ray Data Booklet Y1 - 2009 A1 - Attwood, David A1 - Gullikson, Eric A1 - Howells, Malcolm A1 - Kim, Kwang-Je A1 - Kirz, Janos A1 - Kortright, Jeffrey A1 - Lindau, Ingolf A1 - Liu, Yanwei A1 - Pianetta, Piero A1 - Robinson, Arthur A1 - Scofield, James A1 - Underwood, James A1 - Williams, Gwyn A1 - Winick, Herman PB - Lawrence Berkeley National Laboratory, University of California CY - Berkeley, CA UR - http://xdb.lbl.gov ER - TY - BOOK T1 - Small angle X-ray scattering Y1 - 1982 A1 - Glatter, Otto A1 - Kratky, Otto KW - Science / Physics / Electromagnetism KW - Science / Radiation KW - Small-angle scattering KW - Small-angle x-ray scattering KW - Small-angle x-ray scattering - Scientific applications KW - Small-angle x-ray scattering/ Scientific applications KW - Technology & Engineering / General KW - X-ray crystallography KW - X-ray crystallography - Scientific applications KW - X-ray crystallography/ Scientific applications KW - X-rays PB - Academic Press CY - New York SN - 9780122862809 UR - http://physchem.kfunigraz.ac.at/sm/Software.htm ER - TY - BOOK T1 - X-ray diffraction by polymers Y1 - 1972 A1 - Kakudo, Masao A1 - Kasai, Nobutami KW - Polymers KW - Science / Physics / Crystallography KW - Science / Physics / Optics & Light KW - Technology & Engineering / Textiles & Polymers KW - X-ray crystallography KW - X-rays KW - X-rays - Diffraction PB - Kodansha SN - 9780444410313 ER -