TY - JOUR T1 - A biocompatible hybrid material with simultaneous calcium and strontium release capability for bone tissue repair JF - Materials Science and Engineering: C Y1 - 2016 A1 - Almeida, J. Carlos A1 - András Wacha A1 - Gomes, Pedro S. A1 - Alves, Luís C. A1 - Fernandes, M. Helena Vaz A1 - Salvado, Isabel M. Miranda A1 - Fernandes, M. Helena R. KW - Biocompatible KW - Hybrid materials KW - peer-reviewed KW - Strontium AB -

The increasing interest in the effect of strontium in bone tissue repair has promoted the development of bioactive materials with strontium release capability. According to literature, hybrid materials based on the system PDMS–{}SiO2 have been considered a plausible alternative as they present a mechanical behavior similar to the one of the human bone. The main purpose of this study was to obtain a biocompatible hybrid material with simultaneous calcium and strontium release capability. A hybrid material, in the system PDMS–{}SiO2–{}CaO–{}SrO, was prepared with the incorporation of 0.05 mol of titanium per mol of SiO2. Calcium and strontium were added using the respective acetates as sources, following a sol–{}gel technique previously developed by the present authors. The obtained samples were characterized by FT-IR, solid-state NMR, and SAXS, and surface roughness was analyzed by 3D optical profilometry. In vitro studies were performed by immersion of the samples in Kokubo's SBF for different periods of time, in order to determine the bioactive potential of these hybrids. Surfaces of the immersed samples were observed by SEM, EDS and PIXE, showing the formation of calcium phosphate precipitates. Supernatants were analyzed by ICP, revealing the capability of the material to simultaneously fix phosphorus ions and to release calcium and strontium, in a concentration range within the values reported as suitable for the induction of the bone tissue repair. The material demonstrated to be cytocompatible when tested with MG63 osteoblastic cells, exhibiting an inductive effect on cell proliferation and alkaline phosphatase activity.

VL - 62 ER - TY - JOUR T1 - Amfifil polimer kotérhálók: egy újszerű nanoszerkezetű anyagcsoport JF - Magyar Kémiai Folyóirat - Kémiai Közlemények Y1 - 2015 A1 - Szabó, Ákos A1 - Mezey, Péter A1 - Fodor, Csaba A1 - Domján, Attila A1 - Kali, Gergely A1 - Stumphauser, Tímea A1 - Erdődi, Gábor A1 - Thomann, Ralf A1 - Németh, Péter A1 - Szanka, István A1 - Illés, Gergely A1 - Haraszti, Márton A1 - Pásztor, Szabolcs A1 - Bóta, Attila A1 - András Wacha A1 - Süvegh, Károly A1 - Iván, Béla KW - no-peer-review VL - 121 ER - TY - JOUR T1 - PDMS-SiO2 hybrid materials – A new insight into the role of Ti and Zr as additives JF - Polymer Y1 - 2015 A1 - Almeida, J. Carlos A1 - András Wacha A1 - Bóta, A. A1 - Almásy, L. A1 - Vaz Fernandes, M. Helena A1 - Margaça, Fernanda M. A. A1 - Miranda Salvado, Isabel M. KW - CREDO KW - Hybrid materials KW - Sol–gel KW - Structure AB - The last two decades have seen a remarkable growth in the design of new hybrid materials applied to different areas, from photonics to biomaterials, together with new coating materials with self-cleaning features. Among the various systems studied, the PDMS-SiO2 system remains as a good basis for further developments by adding other compounds such as transition metals. In this work, a detailed study of the influence of titanium or zirconium in the chemical structure and final microstructure of such hybrids was made. It was concluded that, due to the lower reactivity of the titanium alkoxide during the sol–gel preparation process, titanium is preferably located on the surface of secondary particles of silica, unlike the zirconium, which being more reactive, positions on the surface of the primary particles. This difference leads to xerogels with dissimilar characteristics and morphologies. VL - 72 SN - 0032-3861 UR - http://www.sciencedirect.com/science/article/pii/S0032386115300732 JO - Polymer ER - TY - JOUR T1 - Electrically tunable color of mixtures of bent-core and rod-shaped molecules JF - Advanced MaterialsAdvanced Materials Y1 - 2008 A1 - Nair, GG A1 - Bailey, C A1 - Taushanoff, Stefanie A1 - Fodor-Csorba, Katalin A1 - Vajda, Anikó A1 - Varga, Zoltán A1 - Bóta, Attila A1 - Jákli, Antal VL - 20 SN - 0935-9648 IS - 16 JO - Article ER - TY - BOOK T1 - Structure Analysis by Small-Angle X-Ray and Neutron Scattering Y1 - 1987 A1 - Feigin, L. A. A1 - Svergun, D. I. PB - Plenum Press CY - New York SN - 0306426293 UR - http://www.embl-hamburg.de/biosaxs/reprints/feigin_svergun_1987.pdf ER - TY - BOOK T1 - Small-angle scattering of X-rays Y1 - 1955 A1 - Guinier, André A1 - Fournet, Gérard PB - John Wiley & Sons, Inc. CY - New York UR - http://books.google.hu/books?id=5zRRAAAAMAAJ ER -