@article {NaszalyiNagy2015,
	title = {Inherently fluorescent and porous zirconia colloids: preparation, characterization and drug adsorption studies},
	journal = {J. Mater. Chem. B},
	volume = {3},
	number = {38},
	year = {2015},
	pages = {7529{\textendash}7537},
	abstract = {Porous, fluorescent zirconia particles of nearly 380 nm diameter were prepared without template molecules or labeling dyes. The porous structure is the result of aggregation-induced particle formation. The inherent fluorescence is assigned to coordinatively unsaturated Zr4+ ions at the sol{\textendash}{}gel derived ZrO2 surface. After physico-chemical characterization of the native zirconia particles carboxyl and/or amine bearing drug molecules (D,L-\ensuremath{\alpha}-difluoromethylornithine {\textendash}{} DFMO, ursolic acid {\textendash}{} UA and doxorubicin {\textendash}{} DOX) were adsorbed onto their surface, and the products were analyzed with Fourier-transform infrared spectroscopy (FTIR), thermogravimetry (TG), small-angle X-ray scattering (SAXS), fluorimetry and zeta potential vs. pH measurements. We have found that DOX complexes coordinatively unsaturated Zr4+ ions without dislocating them, while carboxyl-bearing drugs interact with basic surface Zr{\textendash}{}OH sites eliminating some of the carbonate species. The adsorption of UA at the zirconia surface shifts considerably the isoelectric point of the surface and thus provides kinetic stability to the particles at physiological pH. An in vivo biodistribution study in two healthy dogs performed by SPECT/CT detection after 99mTc labeling of the nanocarriers has shown the possibility of drug delivery application.},
	keywords = {peer-reviewed},
	issn = {2050-750X, 2050-7518},
	doi = {10.1039/C5TB00832H},
	author = {Nasz{\'a}lyi Nagy, L{\'\i}via and Mih{\'a}ly, Judith and Poly{\'a}k, Andr{\'a}s and Debreczeni, Bal{\'a}zs and Cs{\'a}sz{\'a}r, Barbara and Szigy{\'a}rt{\'o}, Imola Csilla and Andr{\'a}s Wacha and Cz{\'e}g{\'e}ny, Zsuzsanna and Jakab, Emma and Kl{\'e}bert, Szilvia and Drot{\'a}r, Eszter and Dabasi, G and B{\'o}ta, Attila and Balogh, Lajos and Kiss, {\'E}va}
}
@article {96,
	title = {Intercalation of Bovine Serum Albumin Coated Gold Clusters Between Phospholipid Bilayers: Temperature-Dependent Behavior of Lipid-AuQC@BSA Assemblies with Red Emission and Superlattice Structure},
	journal = {The Journal of Physical Chemistry B},
	volume = {118},
	year = {2014},
	month = {April 10, 2014},
	pages = {3887-3892},
	abstract = {<p>A method has been developed to encapsulate bovine serum albumin (BSA)-coated gold quantum clusters (AuQC@BSA) in a multilamellar system of dipalmitoylphosphatidylcholine (DPPC). Results have shown that intercalation of AuQC@BSA particles into lipid bilayers occurs in the presence of CaCl2. Intense red photoluminescence emission was observed after encapsulation of the clusters. A well-defined structure was found with periodic distances drastically larger than that in the pure DPPC/water system. Although Ca2+ ions can change the dipole characteristics of the lipid bilayer surface, leading to unbinding between the bilayers of multilamellar DPPC/water system, the repulsion is shielded in the presence of AuQC@BSA particles. A coherent superlattice structure evolves due to mixed Ca2+-DPPC and Ca2+-AuQC@BSA interactions. Studies at different temperatures have suggested a correlation between the luminescence properties of the clusters and phase transition of the lipid layers. The temperature-dependent behavior assumes the connection between the coating and the lipid bilayer surface. Temperature-dependent features of lipid intercalated Au clusters provide new opportunities in their application.</p>
},
	isbn = {1520-6106},
	url = {http://dx.doi.org/10.1021/jp4124138},
	author = {S{\"o}ptei, Bal{\'a}zs and Mih{\'a}ly, Judith and Visy, J{\'u}lia and Andr{\'a}s Wacha and B{\'o}ta, Attila}
}
